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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Apr 26;57(21):6082–6085. doi: 10.1002/anie.201713403

Scheme 1.

Scheme 1

Reactions catalyzed by CYP112, CYP68B and GA20ox in GA biosynthesis from bacteria, fungi and plants, respectively. Sequential oxidation and elimination of C-20, while the plant and fungal enzyme release CO2 upon elimination of C-20, this was unknown for the bacterial CYP112.