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. Author manuscript; available in PMC: 2018 Jun 27.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Jan 31;127:106–118. doi: 10.1016/j.addr.2018.01.015

Fig. 7.

Fig. 7

A) Schematic of the smart insulin patch composed of HA and GRVs composed of HA. B) Formation and mechanism of glucose-responsive MN patch. C) The indicated mouse skin was applied with an MN-array patch (Scale bar: top right 500 μm, bottom 100 μm). D) In vivo BG level changes E) and plasma human insulin concentrations in diabetic mice after indicated treatments.

Adapted with permission from Ref [41].