Table 3.

Univariate and multivariate analyses of overall survival.

Parameter	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Age	1.00	0.99 to 1.02	0.548
Sex
Male vs. female	0.78	0.49 to 1.24	0.294
Stage
Stage 4 vs. stage 3	0.22	0.07 to 0.69	0.010	4.04	1.27 to 12.89	0.018
Tumor mutational burden
Continuous variable	1.00	1.00 to 1.00	0.206
≥ median vs. <median	0.72	0.47 to 1.11	0.143	0.56	0.36 to 0.88	0.012
Indel burden
≥75th percentile vs.	0.92	0.57 to 1.49	0.739
<75th percentile
LDH
Abnormal vs. normal	2.07	1.33 to 3.22	0.001	2.58	1.61 to 4.14	<0.001
TP53
Mutation vs. wild-type	2.05	1.02 to 4.13	0.044	3.27	1.52 to 7.02	0.002
BRAFV600E
Mutation vs. wild-type	0.70	0.43 to 1.16	0.165

LDH, lactate dehydrogenase.