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. 2018 May 26;32:31–42. doi: 10.1016/j.ebiom.2018.05.023

Fig. 6.

Fig. 6

The change of NLRP3 inflammsome in BA-MSCs after administration with 66PR in vivo.

(a) The experimental animal scheme. (b) The body weight analysis of colitis mice injected with 66PR and PBS. (c) The clinical scores of colitis mice injected with 66PR and PBS. (d) The colon length of colitis mice injected with 66PR and PBS. (e) The H&E stained colon sections from colitis mice injected with 66PR and PBS. (f) The histological scores of colitis and control mice. (g) Western blot analysis of NLRP3, caspase-1, IL-1β proteins in BA-MSCs from colitis mice injected with 66PR and PBS. (h-j) Densitometry analyses of NLRP3, caspase-1 and IL-1β according to (g). (k) Confocal laser scanning microscopic analysis of GSDMDC1 (green), CD51 (red) and nuclei (DAPI, blue) of bone sections from IBD mice injected with 66PR and PBS. Each experiment represents at least four mice per group. Eight sections were observed per group. Mean ± SD, t-test, *P < 0.05,**P < 0.01,***P < 0.001, ns: not significant, nd: not detected.