Table 1.
Contractile and morphological properties of soleus muscles in sham and MIUH rats.
| Sham | MIUH | |
|---|---|---|
| (n = 8) | (n = 9) | |
| CONTRACTILE PROPERTIES | ||
| TTP (ms) | 49 ± 8 | 52 ± 8 |
| HRT (ms) | 54 ± 4 | 44 ± 4*** |
| P20/P0 (%) | 48 ± 5 | 50 ± 10 |
| Pt (mN) | 8.03 ± 1.44 | 6.31 ± 1.34* |
| P0 (mN) | 61.35 ± 5.92 | 55.56 ± 11.39† |
| Pt/MWW(mN/mg) | 0.22 ± 0.05 | 0.18 ± 0.03† |
| P0/MWW (mN/mg) | 1.70 ± 0.36 | 1.49 ± 0.28 |
| Pt/P0 | 12.41 ± 1.22 | 12.10 ± 1.58 |
| FI (%) | 86 ± 9 | 78 ± 26 |
| MORPHOLOGICAL PARAMETERS | ||
| BW (g) | 95 ± 7 | 89 ± 11 |
| MWW (mg) | 38 ± 4 | 34 ± 4 |
| MWW/BW (mg/g) | 0.40 ± 0.05 | 0.40 ± 0.04 |
| HISTOCHEMICAL PROPERTIES | ||
| MHC 1 | 67.1 ± 13.3% | 55.8 ± 12.7% |
| MHC2A | 32.2 ± 12.5% | 40.3 ± 11.9% |
| MHC2B | 0.2 ± 0.4% | 0.0 ± 0.0% |
| MHC neonatal | 0.5 ± 1.4% | 3.9 ± 2.7%** |
Pt, single twitch tension; P0, tetanic tension at 100 Hz; P20, tetanic tension at 20 Hz; FI, fatigue index; BW, body weight; MWW, muscle wet weight.
*, **, ***
A significant difference with respect to sham rats at p < 0.05, p < 0.01, p < 0.001, respectively.
†
A tendency (p < 0.1). Mean ± SD.