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. 2018 Jun 20;9:1293. doi: 10.3389/fimmu.2018.01293

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Copyright © 2018 Shah, Imami and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic natural killer (NK) cell subtype with the phenotype CD16⁺CD56^lo are reduced and show an increase in P4-induced blocking factor (PIBF) expression in late pregnancy. (A) Representative flow cytometry plots are shown for NK cell subsets. (B) Longitudinal analysis of CD16⁺CD56^lo and their PIBF expression during pregnancy and compared with gestation matched controls. Gestation at sampling is indicated in pregnancy (●): <20⁺⁰ weeks (N = 42), 28 weeks (N = 35), 34 weeks (N = 33), at delivery (N = 24), 24 h post-delivery (N = 22), 6–8 weeks postnatal (N = 13). Non-pregnant controls are depicted as (N = 14). P values are two tailed and significance is defined as *P < 0.05 and ***P < 0.001. Non-pregnant and baseline pregnant data analyzed by Mann––Whitney U test. Longitudinal data analyzed by generalized linear mixed effects model with gamma log-link and pairwise multiple comparisons of estimated marginal means with sequential Bonferroni correction.

Inline graphic — Cytotoxic natural killer (NK) cell subtype with the phenotype CD16⁺CD56^lo are reduced and show an increase in P4-induced blocking factor (PIBF) expression in late pregnancy. (A) Representative flow cytometry plots are shown for NK cell subsets. (B) Longitudinal analysis of CD16⁺CD56^lo and their PIBF expression during pregnancy and compared with gestation matched controls. Gestation at sampling is indicated in pregnancy (●): <20⁺⁰ weeks (N = 42), 28 weeks (N = 35), 34 weeks (N = 33), at delivery (N = 24), 24 h post-delivery (N = 22), 6–8 weeks postnatal (N = 13). Non-pregnant controls are depicted as (N = 14). P values are two tailed and significance is defined as *P < 0.05 and ***P < 0.001. Non-pregnant and baseline pregnant data analyzed by Mann––Whitney U test. Longitudinal data analyzed by generalized linear mixed effects model with gamma log-link and pairwise multiple comparisons of estimated marginal means with sequential Bonferroni correction.