Figure 7.

Baseline concentrations of pro-inflammatory cytokines in the P4-treated group are reduced. Plasma concentrations of cytokines measured by 17-plex multiplex assay were determined. (A) Longitudinal analysis of IFN-γ and IL-7 concentrations of noted in the P4 treated group. (B) IFN-γ and IL-7 concentrations in P4 treated compared to gestation-matched controls. Unpaired Mann–Whitney U test. (C) Longitudinal analysis of RU486 effect on plasma cytokine concentrations. A representative sample of patients (N = 6) were assessed. Gestation at sampling is indicated: in pregnant controls (●) at <20⁺⁰ weeks (N = 42), 28 weeks (N = 35), 34 weeks (N = 33); and P4 treated pregnancies (⚪) at <20⁺⁰ weeks (N = 15), 28 weeks (N = 11), 34 weeks (N = 11), 36 weeks (N = 10). For RU486 treated (N = 6) symbols represent individual patients. Longitudinal data were analyzed with Freidman test with Dunn’s post hoc correction. P values are two tailed and significance is defined as *P < 0.05.