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. 2018 Jun 20;9:1293. doi: 10.3389/fimmu.2018.01293

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Copyright © 2018 Shah, Imami and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RU486 treatment is associated with reduced proportions of CD4 and CD8 differentiated effector memory subtypes. (A) Longitudinal analysis of proportions of CD4⁺CCR7⁻CD45RA⁻ T_EM and (B) CD8 T_EM (CCR7⁻CD45RA⁻) in RU486-treated (N = 8) symbols represent individual patients. P values are two tailed and significance is defined as *P < 0.05, by Freidman test with Dunn’s post hoc correction. Representative flow cytometry plots of (C) singlet CD4⁺ lymphocytes co-expressing CCR7 and CD45RA is shown with percentages of T_EM cell, and (D) singlet CD8⁺ lymphocytes co-expressing CCR7 and CD45RA is shown with percentages of T_EM and T_TEMRA cells. Populations were gated using isotype controls.