Table 5.

Comparison of high-risk smoldering multiple myeloma

n = 90*	n (%)	Median TTP, mo	Log-rank P	2-y PD, %	Overall PD, %	Specificity, %	Sensitivity, %	Diagnostic accuracy	2-y AUC	Integrated time-dependent AUC
Mayo Clinic baseline score†
1	37 (41)	96.1	.0218	8	32
2	43 (48)	48.1		26	44
3	10 (11)	24.7		50	80	93	25	79	0.70	0.59
Mayo Clinic evolving score‡
0	10 (11)	115.2	<.0001	0	20
1	34 (38)	96.1		9	35
2	24 (27)	NR		21	33
3	22 (24)	21.8		50	77	85	58	79	0.78	0.68
Mount Sinai multivariable score§
0	29 (32)	NR	<.0001	3	14
1	36 (40)	77.3		11	42
2	17 (19)	26.3		41	71	86	74
3 or 4	8 (9)	13.4		88	100	99	35	86	0.85	0.74

^*Patients were required to have all listed variables described for the complete case analysis.

^†BMPC ≥10%, m-protein ≥3 g/dL, FLCr ≥8.

^‡BMPC ≥20%, eMP (≥10% increase in m-protein and/or immunoglobulin within the first 6 mo and/or ≥25% increase in m-protein and/or immunoglobulin within the first 12 mo), eHb (≥0.5 g/dL decrease within the first 12 mo).

^§Immunoparesis, eHb GBTM, eMP GBTM, edFLC GBTM.