Figure 1.
NK phenotype and response before and after allogeneic HSCT in 3 HIV-infected individuals on suppressive ART. (A) The percentage of lymphocytes that are NK cells, (B) percentage of CD56dimCD16+ NK cells, (C) percentage of CD56−CD16+ NK cells, (D) percentage of CD56brightCD16− NK cells, (E) percentage of CD57+ NK cells, and (F) percentage of NK cells expressing inhibitory KIRs are shown. The percentage of cells expressing a surrogate marker for cytotoxic degranulation (CD107a) and INF-γ in response to MHC-deficient target cells are shown in panels G and H, respectively. Participants (Pt) 1, 2, and 3 experienced decrease in CD4+ T cell-associated HIV-1 DNA levels 5.8, 6.4, and 1 month following HSCT, respectively. Post-HSCT chimerisms for Participants 1, 2, and 3 were 94% donor leukocyte, 89% donor leukocyte (24% Donor T-cell), and 87% donor leukocyte, respectively. M, myeloablative conditioning; RIC, reduced-intensity HSCT conditioning.