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. 2016 Apr 26;7(8):5407–5413. doi: 10.1039/c6sc00012f

Fig. 1. Rational design of HKYellow used for the detection of peroxynitrite. (a) Generalization of HKGreen-4 for designing new peroxynitrite probes with varying excitation and emission colors. (b) Structural combination of rhodamine B and X-rhodamine and incorporation of a carboxylate group leading to the new rhodamine scaffold used for constructing HKYellow, which is virtually non-fluorescent yet reacts with peroxynitrite to yield a strongly fluorescent product 2. (c) The structure of the cell membrane permeable HKYellow-AM and its conversion to HKYellow by intracellular esterases.

Fig. 1