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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Macromol Biosci. 2017 Mar 24;17(7):10.1002/mabi.201600554. doi: 10.1002/mabi.201600554

Figure 1.

Figure 1

Schematic showing the structure of a fusion molecule consisting of a cell-penetrating peptide and a temperature-sensitive elastin-like polypeptide (ELP) domain bound to a paclitaxel prodrug through a thiol reaction to an acid-sensitive linker. Investigational New Drugs, A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis, 30, 2012, 236, Shama Moktan, Claudia Ryppa, Feliz Kratz, Drazen Raucher, Copyright Springer Science+Business Media, LLC 2010, with permission of Springer