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. Author manuscript; available in PMC: 2018 Jun 27.
Published in final edited form as: Semin Liver Dis. 2018 Feb 22;38(1):51–59. doi: 10.1055/s-0037-1621710

Figure 2. FLC and HCC have distinct molecular characteristics.

Figure 2

The transcriptome of fibrolamellar tumor relative to the adjacent normal and hepatocellular carcinoma tumor, relative to the adjacent normal, were analyzed and characterized by hierarchical clustering (complete method) with a spearman rank correlation matrix for all 3708 protein coding genes that passed the DESeq2 expression filter (|log 2 fold change| > 1, FDR < 0.01, and ranked by moderated t statistic ranking). The transcriptome of the fibrolamellar samples (purple) segregated away from those of hepatocellular carcinoma (orange) [Data shown is for 10 FLC and 42 HCC from over 400 HCC patients analyzed]. An example is shown of one patient out of five found that had been reported to be HCC, but the transcriptome segregated with FLC. This particular example was from a young adolescent who was diagnosed with HCC without a molecular characterization. An analysis showed the presence of a fusion between the genes DNAJB1 and PRKACA consistent with this patient actually having fibrolamellar (see figure 3). A histological sample was not available in this specific case. Figure from (10).