Table 5. . Univariate and multivariate Cox proportional hazard model of overall survival for post-treatment health-related quality of life at month 1.
| Factor | p-value | HR | 95% CI of HR† | |
|---|---|---|---|---|
| Univariate analysis | ||||
| Age at baseline (years) | 0.0052 | 1.020 | 1.006 | 1.035 |
| Age ≥65 years (1 = yes, 0 = no) | 0.0098 | 1.507 | 1.104 | 2.057 |
| KPS score | 0.0139 | 0.988 | 0.978 | 0.997 |
| KPS <70 (1 = yes, 0 = no) | 0.0130 | 1.560 | 1.098 | 2.216 |
| Gender (1 = male, 0 = female) | 0.3981 | 0.860 | 0.606 | 1.220 |
| Primary cancer site: | 0.0224 | |||
| – GI vs breast | 0.0102 | 3.462 | 1.342 | 8.928 |
| – GU vs breast | 0.0117 | 2.497 | 1.226 | 5.086 |
| – Lung vs breast | 0.0637 | 1.443 | 0.979 | 2.128 |
| – Other vs breast | 0.0422 | 1.946 | 1.024 | 3.699 |
| – Unknown vs breast | 0.0987 | 2.212 | 0.862 | 5.677 |
| QOL changes: | ||||
| – GHS: | 0.7938 | – | – | – |
| • Decrease vs no change | 0.9890 | 1.003 | 0.668 | 1.506 |
| • Increase vs no change | 0.5363 | 0.856 | 0.524 | 1.400 |
| – Physical functioning: | 0.5284 | – | – | – |
| • Decrease vs no change | 0.4434 | 1.307 | 0.659 | 2.592 |
| • Increase vs no change | 0.9254 | 0.964 | 0.450 | 2.065 |
| – Emotional functioning: | 0.2490 | – | – | – |
| • Decrease vs no change | 0.2736 | 0.701 | 0.372 | 1.324 |
| • Increase vs no change | 0.1065 | 0.641 | 0.374 | 1.100 |
| – Social functioning: | 0.5338 | – | – | – |
| • Decrease vs no change | 0.2775 | 1.939 | 0.587 | 6.402 |
| • Increase vs no change | 0.8681 | 1.125 | 0.280 | 4.520 |
| – Future uncertainty: | 0.9347 | – | – | – |
| • Decrease vs no change | 0.8502 | 1.096 | 0.425 | 2.822 |
| • Increase vs no change | 0.7233 | 1.196 | 0.444 | 3.219 |
| – Visual disorder: | 0.2006 | – | – | – |
| • Decrease vs no change | 0.4660 | 1.367 | 0.590 | 3.172 |
| • Increase vs no change | 0.1263 | 0.388 | 0.115 | 1.306 |
| – Motor dysfunction: | 0.3342 | – | – | – |
| • Decrease vs no change | 0.2925 | 1.506 | 0.703 | 3.228 |
| • Increase vs no change | 0.1549 | 1.915 | 0.782 | 4.688 |
| – Concentration difficulty: | 0.5672 | – | – | – |
| • Decrease vs no change | 0.3388 | 1.432 | 0.686 | 2.992 |
| • Increase vs no change | 0.4624 | 1.458 | 0.533 | 3.984 |
| Multivariate analysis | ||||
| Age ≥65 years (1 = yes, 0 = no) | 0.0184 | 1.460 | 1.066 | 2.001 |
| KPS <70 (1 = yes, 0 = no) | 0.0301 | 1.479 | 1.038 | 2.107 |
†For GHS and domain-changed scores (decrease or increase vs no change), HR >1 indicates that the hazard of death in patients with decreased or increased HRQOL scores has (HR - 1) × 100% higher than the hazard of patients with nonchanged scores; HR <1 indicates that the hazard of patients with decreased or increased HRQOL scores has (1 - HR) × 100% lower than the hazard of patients with nonchanged scores.
GHS: Global health status; GI: Gastrointestinal; GU: Genitourinary; HR: Hazard ratio; HRQOL: Health-related quality of life; KPS: Karnofsky performance status; QOL: Quality of life.