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. 2018 Jun 22;12:1837–1853. doi: 10.2147/DDDT.S162950

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© 2018 Feng et al. This work is published and licensed by Dove Medical Press Limited

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Salidroside inhibited ECM production and regulated the balance between MMP2 and TIMP1.

Notes: (A) Western blot and quantitative analyses. Salidroside decreased Col-1, α-SMA, and TIMP1 levels and increased MMP2 levels in the two liver fibrosis mouse models, compared with CCl₄ or BDL treatment alone. (B) The qPCR analyses. Salidroside downregulated mRNA expression levels of Col-1α1, Col-1α2, α-SMA, and TIMP1 and upregulated MMP2 mRNA. (C) Immunohistochemical staining showed that the increased expression levels of Col-1 and α-SMA proteins in liver tissues in both CCl₄ and BDL groups were ameliorated by salidroside (original magnification, ×200, scale bars =100 μm). Data were given as mean ± SD (n=8, *P<0.05 for CCl₄ or BDL group vs vehicle or sham group, ^#P<0.05 for CCl₄ + Sal 10 mg/kg or BDL + Sal 10 mg/kg vs CCl₄ or BDL group, and ⁺P<0.05 for CCl₄ + Sal 20 mg/kg or BDL + Sal 20 mg/kg vs CCl₄ + Sal 10 mg/kg or BDL + Sal 10 mg/kg).

Abbreviations: BDL, bile duct ligation; CCl₄, carbon tetrachloride; ECM, extracellular matrix; qPCR, quantitative real-time polymerase chain reaction; Sal, salidroside; SD, standard deviation.

Salidroside inhibited ECM production and regulated the balance between MMP2 and TIMP1.

Notes: (A) Western blot and quantitative analyses. Salidroside decreased Col-1, α-SMA, and TIMP1 levels and increased MMP2 levels in the two liver fibrosis mouse models, compared with CCl₄ or BDL treatment alone. (B) The qPCR analyses. Salidroside downregulated mRNA expression levels of Col-1α1, Col-1α2, α-SMA, and TIMP1 and upregulated MMP2 mRNA. (C) Immunohistochemical staining showed that the increased expression levels of Col-1 and α-SMA proteins in liver tissues in both CCl₄ and BDL groups were ameliorated by salidroside (original magnification, ×200, scale bars =100 μm). Data were given as mean ± SD (n=8, *P<0.05 for CCl₄ or BDL group vs vehicle or sham group, ^#P<0.05 for CCl₄ + Sal 10 mg/kg or BDL + Sal 10 mg/kg vs CCl₄ or BDL group, and ⁺P<0.05 for CCl₄ + Sal 20 mg/kg or BDL + Sal 20 mg/kg vs CCl₄ + Sal 10 mg/kg or BDL + Sal 10 mg/kg).

Abbreviations: BDL, bile duct ligation; CCl₄, carbon tetrachloride; ECM, extracellular matrix; qPCR, quantitative real-time polymerase chain reaction; Sal, salidroside; SD, standard deviation.