Table 3.
DPPH-reducing ability, IC50 values of soybean lipoxygenase (LOX) inhibition in vitro and anti-lipid peroxidation activity (LP) of compounds 5a–f.
| DPPH-reducing abilitya (%) |
||||
|---|---|---|---|---|
| Compd. | 20 min | 60 min | LOX inhibition (IC50 μM) ± SD | LP inhibitiona (%) ± SD |
| 5a | 6b | 5b | 40.0 ± 1.0a,c | 15 ± 0.7 |
| 5b | 7b | 5b | 69.0 ± 2.0 | 92 ± 3.2 |
| 5c | 2b | 2b | 40.0 ± 1.5 | 99 ± 2.8 |
| 5d | 1b | 2b | 41.5 ± 3.1 | 90 ± 4.5 |
| 5e | 1b | 1b | 56.0 ± 2.3 | 80 ± 2.7 |
| 5f | 2b | 2b | 67.5 ± 1.1 | 90 ± 3.6 |
| NDGA | 83.0 ± 1.0 | 91.0 ± 1.7 | 0.45 ± 0.01 | nt |
| Trolox | nt | nt | Nt | 96 ± 2.0 |
aConcentration of the tested compounds: 100 μΜ.
bnon-significant.
cper cent.
Nt: not tested; SD: standard deviation.