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. Author manuscript; available in PMC: 2018 Oct 18.
Published in final edited form as: Nature. 2018 Apr 18;556(7702):510–514. doi: 10.1038/s41586-018-0048-8

Extended data Figure 9. ESC TFs binding in poised enhancer.

Extended data Figure 9

a, Profile of 214 macrophage enhancers, which have poised chromatin signatures in ESCs. b, ESC transcription factors (Oct4, Sox2, Nanog, Esrrb, E2f1, Tcfcp2l1, Zfx and Klf4) were analyzed in 129 macrophage enhancers to test binding of ESC TFs. These 129 macrophage enhancers were obtained based on the criteria; high H3K27me3 in ESCs and high H3K27Ac (over 20 tags) in macrophage. Data from published sources are listed in Supplementary Table 1. c, Schematic diagram of Pu.1 enhancers. d, Genome browser screenshot of the poised Pu.1 enhancers. Blue arrow indicates Esrrb binding region and red arrow indicates Oct4 binding region. Red box indicates four clustered putative Pu.1 enhancers.