Table 1.
Characteristics of the clinical prostate cancers tested ex vivo in explant organ cultures for responsiveness to AZD1480.
| Variables | Responders | Non-responders |
|---|---|---|
| n | 9 | 3 |
| Median (range) | Median (range) | |
| Age at radical prostatectomy | 62 (47-67) | 66 (58-67) |
| AUA score | 6.5 (2-21.5) | 9.5 (5-14) |
| IIEF score | 23 (3-25) | 13.5 (2-25) |
| Gleason score | n (%) | n (%) |
| 4 | 0 (0) | 0 (0) |
| 5 | 0 (0) | 0 (0) |
| 6 | 1 (11.1) | 0 (0) |
| 7 | 7 (77.8) | 2 (66.6) |
| 8 | 0 (0) | 0 (0) |
| 9 | 1 (11.1) | 1 (33.3) |
| 10 | 0 (0) | 0 (0) |
| Unknown | 0 (0) | 0 (0) |
| Stage | n (%) | n (%) |
| T1c | 7 (77.8) | 0 (0) |
| T2a | 1 (11.1) | 0 (0) |
| T2b | 0 (0) | 1 (33.3) |
| T2c | 1 (11.1) | 1 (33.3) |
| T3a | 0 (0) | 1 (33.3) |
| Metastases detected | n (%) | n (%) |
| Yes | 0 (0) | 0 (0) |
| No | 8 (88.9) | 3 (100) |
| Unknown | 1 (11.1) | 0 (0) |
AUA score = American Urological Association symptom score: degree of urinary symptoms – none (0); mild (1-7); moderate (8-19); severe (20-35).
IIEF score = International Index of Erectile Function score: degree of erectile dysfunction – none (22-25); mild (17-21); mild to moderate (12-16); moderate (8-11); severe (5-7).