Figure 2.

Effect of SB-3CT on BBB leakage in tPA-treated mice after embolic ischemia. A, BBB leakage as ascertained by IgG extravasation. Representative brain sections from the same mice described in Figure 1 were stained with goat anti-mouse IgG. IgG extravasation for tPA given at 4 h (B) or 6 h (C) postischemia; *p < 0.05 by one-tailed Student’s t test.