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. 2018 Jun 27;5(3):ENEURO.0138-18.2018. doi: 10.1523/ENEURO.0138-18.2018

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Copyright © 2018 Taylor et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — Destabilization of nodes leads to axonopathy in adult CNS myelinated axons. A–J, TEM of cross sections from SCs of NF^fx;Ank^fx control (A, C) and SLICK-H-CreER;NF^fx;Ank^fx (B, D–J) mice 60 days after P23/24 injection. Green arrowheads point to normal axons, greens arrows to compact myelin, red arrowheads to abnormal accumulations in the periaxonal space, and red asterisks to vacuoles. K–N, TEM of longitudinal sections from SCs of NF^fx;Ank^fx (K, M) and SLICK-H-CreER;NF^fx;Ank^fx (L–L′, N) mice 60 dpi focusing on the nodal and paranodal areas. Black arrows mark paranodal axo-glial septate-like junctions. Scale bar for A–J = 2 μm, K–L′ = 0.5 μm, M, N = 0.2 μm.