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. 2018 Jun 27;5(3):ENEURO.0138-18.2018. doi: 10.1523/ENEURO.0138-18.2018

Table 1.

Statistical summary

Item Figure Data structure Type of test Description Comparison Power
a 1F Normal distribution Mantel–Cox log rank test; Bonferroni post hoc analysis; K = 6 Survival postinjection
Control vs. P13 ablation DKO χ2 = 51.18; p < 0.0001
P13 ablation DKO vs. P23 ablation DKO χ2 = 25.28; p < 0.0001
P13 ablation DKO vs. P93 ablation DKO χ2 = 17.72; p < 0.0001
Control vs. P23 ablation DKO x2 = 31.28; p < 0.0001
P23 ablation vs. P93 ablation χ2 = 18.68; p < 0.0001
Control vs. P93 ablation χ2 = 8.0; p = 0.0047
b 1G Normal distribution Two-way ANOVA; Tukey post hoc analysis P13 ablation: body weight
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p = 0.4746
Control 10 dpi vs. DKO 10 dpi p = 0.1806
Control 20 dpi vs. DKO 20 dpi p = 0.0038
Control 30 dpi vs. DKO 30 dpi p = 0.0023
c 1H Normal distribution Two-way ANOVA; Tukey post hoc analysis P23 ablation: body weight
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0457
Genotype × timing interaction p = 0.0002
Control 10 dpi vs. DKO 10 dpi p = 0.9953
Control 20 dpi vs. DKO 20 dpi p = 1943
Control 60 dpi vs. DKO 60 dpi p < 0.0001
d 1I Normal distribution Two-way ANOVA; Tukey post hoc analysis P93 ablation: body weight
Effect of genotype p = 1410
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p = 0.2562
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi p = 0.9996
Control 1200 dpi vs. DKO 120 dpi p = 0.3155
e 2J, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. Ank cKO 10 dpi p = 0.0694
Control 20 dpi vs. Ank cKO 20 dpi p < 0.0001
Control 30 dpi vs. Ank cKO 30 dpi p < 0.0001
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
Ank cKO 10 dpi vs. 20 dpi p = 0.0010
Ank cKO 10 dpi vs. 30 dpi p < 0.0001
Ank cKO 20 dpi vs. 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p > 0.9999
DKO 10 dpi vs. 30 dpi p = 0.9997
DKO 20 dpi vs. 30 dpi p > 0.9999
f 2J, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 30 dpi vs. Ank cKO 30 dpi p > 0.9999
Control 10 dpi vs. DKO 10 dpi p = 0.9984
Control 20 dpi vs. DKO 20 dpi p = 0.0015
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0042
DKO 10 dpi vs. 30 dpi p < 0.0001
DKO 20 dpi vs. 30 dpi p < 0.0001
g 2J′, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. Ank cKO 10 dpi p < 0.0001
Control 20 dpi vs. Ank cKO 20 dpi p < 0.0001
Control 30 dpi vs. Ank cKO 30 dpi p < 0.0001
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
Ank cKO 10 dpi vs. 20 dpi p = 0.0011
Ank cKO 10 dpi vs. 30 dpi p < 0.0001
Ank cKO 20 dpi vs. 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.9973
DKO 10 dpi vs. 30 dpi p > 0.9998
DKO 20 dpi vs. 30 dpi p = 0.9996
h 2J′, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 30 dpi vs. Ank cKO 30 dpi p > 0.9999
Control 10 dpi vs. DKO 10 dpi p = 0.5624
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0001
DKO 10 dpi vs. 30 dpi p < 0.0001
DKO 20 dpi vs. 30 dpi p < 0.0001
i 2K, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. Ank cKO 10 dpi p = 0.9389
Control 20 dpi vs. Ank cKO 20 dpi p < 0.0001
Control 60 dpi vs. Ank cKO 60 dpi p < 0.0001
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 60 dpi vs. DKO 60 dpi p < 0.0001
Ank cKO 10 dpi vs. 20 dpi p = 0.0008
Ank cKO 10 dpi vs. 60 dpi p < 0.0001
Ank cKO 20 dpi vs. 60 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p > 0.9999
DKO 10 dpi vs. 60 dpi p > 0.9999
DKO 20 dpi vs. 60 dpi p = 0.8804
j 2K, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 60 dpi vs. Ank cKO 60 dpi p > 0.9999
Control 10 dpi vs. DKO 10 dpi p = 0.9943
Control 20 dpi vs. DKO 20 dpi p = 0.0031
Control 60 dpi vs. DKO 60 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0089
DKO 10 dpi vs. 60 dpi p < 0.0001
DKO 20 dpi vs. 60 dpi p < 0.0001
k 2K′, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. Ank cKO 10 dpi p < 0.0001
Control 20 dpi vs. Ank cKO 20 dpi p < 0.0001
Control 60 dpi vs. Ank cKO 60 dpi p < 0.0001
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 60 dpi vs. DKO 60 dpi p < 0.0001
Ank cKO 10 dpi vs. 20 dpi p < 0.0001
Ank cKO 10 dpi vs. 60 dpi p < 0.0001
Ank cKO 20 dpi vs. 60 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p > 0.9999
DKO 10 dpi vs. 60 dpi p > 0.9999
DKO 20 dpi vs. 60 dpi p = 0.9991
l 2K′, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 60 dpi vs. Ank cKO 60 dpi p > 0.9999
Control 10 dpi vs. DKO 10 dpi p = 0.6324
Control 20 dpi vs. DKO 20 dpi p = 0.0001
Control 60 dpi vs. DKO 60 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0009
DKO 10 dpi vs. 60 dpi p < 0.0001
DKO 20 dpi vs. 60 dpi p < 0.0001
m 2L, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.9562
Genotype × timing interaction p = 0.1124
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.7683
DKO 10 dpi vs. 120 dpi p = 0.9502
DKO 20 dpi vs. 120 dpi p = 0.9925
n 2L, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.1372
Control 20 dpi vs. DKO 20 dpi p = 0.0182
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.9704
DKO 10 dpi vs. 120 dpi p < 0.0001
DKO 20 dpi vs. 120 dpi p < 0.0001
o 2L′, AnkG Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: AnkG nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0083
Genotype × timing interaction p = 0.0063
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.1040
DKO 10 dpi vs. 120 dpi p = 0.0010
DKO 20 dpi vs. 120 dpi p = 0.2210
p 2L′, NF186 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: NF186 nodal count
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.9167
Control 20 dpi vs. DKO 20 dpi p = 0.4298
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.9131
DKO 10 dpi vs. 120 dpi p < 0.0001
DKO 20 dpi vs. 120 dpi p < 0.0001
q 2M, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: NF186 intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0001
Genotype × timing interaction p = 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.4702
Control 20 dpi vs. DKO 20 dpi p = 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0125
DKO 10 dpi vs. 30 dpi p < 0.0001
DKO 20 dpi vs. 30 dpi p = 0.0036
r 2M, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: NF186 intensity
Effect of genotype p = 0.0007
Effect of timing postinjection p = 0.0308
Genotype × timing interaction p = 0.0308
Control 10 dpi vs. DKO 10 dpi p = 0.9972
Control 20 dpi vs. DKO 20 dpi p = 0.2550
Control 60 dpi vs. DKO 60 dpi p = 0.0029
DKO 10 dpi vs. 20 dpi p = 0.5495
DKO 10 dpi vs. 60 dpi p = 0.0070
DKO 20 dpi vs. 60 dpi p = 0.1800
s 2M, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: NF186 intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi p = 0.2330
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.2696
DKO 10 dpi vs. 120 dpi p < 0.0001
DKO 20 dpi vs. 120 dpi p = 0.0003
t 2M′, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: NF186 intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0003
Genotype × timing interaction p = 0.0003
Control 10 dpi vs. DKO 10 dpi p = 0.9382
Control 20 dpi vs. DKO 20 dpi p = 0.0971
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.5018
DKO 10 dpi vs. 30 dpi p < 0.0001
DKO 20 dpi vs. 30 dpi p = 0.0009
u 2M′, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: NF186 intensity
Effect of genotype p = 0.0013
Effect of timing postinjection p = 0.0112
Genotype × timing interaction p = 0.0113
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi p = 0.5115
Control 60 dpi vs. DKO 60 dpi p = 0.0010
DKO 10 dpi vs. 20 dpi p = 0.6657
DKO 10 dpi vs. 60 dpi p = 0.0028
DKO 20 dpi vs. 60 dpi p = 0.0329
v 2M′, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: NF186 intensity
Effect of genotype p = 0.0007
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi p = 0.9996
Control 120 dpi vs. DKO 120 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.9978
DKO 10 dpi vs. 120 dpi p < 0.0001
DKO 20 dpi vs. 120 dpi p < 0.0001
w 2Q Normal distribution Unpaired, two-tailed t test SN P13 ablation: relative protein level
AnkG level: control vs. Ank cKO p = 0.0002
AnkG level: control vs. DKO p = 0.006
NF186 level: control vs. Ank cKO p = 0.9415
NF186 level: control vs. DKO p = 0.0062
× 2Q′ Normal distribution Unpaired, two-tailed t test SC P13 ablation: relative protein level
AnkG level: control vs. Ank cKO p = 0.0079
AnkG level: control vs. DKO p = 0.0013
NF186 level: control vs. Ank cKO p = 0.355
NF186 level: control vs. DKO p = 0.0003
y 2R Normal distribution Unpaired, two-tailed t test SN P23 ablation: relative protein level
AnkG level: control vs. Ank cKO p = 0.0404
AnkG level: control vs. DKO p = 0.0046
NF186 level: control vs. Ank cKO p = 0.3541
NF186 level: control vs. DKO p = 0.0249
z 2R′ Normal distribution Unpaired, two-tailed t test SC P23 ablation: relative protein level
AnkG level: control vs. Ank cKO p = 0.0036
AnkG level: control vs. DKO p = 0.0016
NF186 level: control vs. Ank cKO p = 0.7327
NF186 level: control vs. DKO p = 0.0066
aa 2S Normal distribution Unpaired, two-tailed t test SN P93 ablation: relative protein level
AnkG level: control vs. DKO p = 0.0043
NF186 level: control vs. DKO p < 0.0001
ab 2S′ Normal distribution Unpaired, two-tailed t test SC P93 ablation: relative protein level
AnkG level: control vs. DKO p = 0.0009
NF186 level: control vs. DKO p = 0.0002
ac 3S, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: NaV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.9992
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 30 dpi p < 0.0001
DKO 20 dpi vs. 30 dpi p < 0.0001
ad 3S, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: NaV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0002
Genotype × timing interaction p = 0.0002
Control 10 dpi vs. DKO 10 dpi p = 0.9996
Control 20 dpi vs. DKO 20 dpi p = 0.0003
Control 60 dpi vs. DKO 60 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.0011
DKO 10 dpi vs. 60 dpi p < 0.0001
DKO 20 dpi vs. 60 dpi p = 0.93009
ae 3S, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: NaV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0027
Genotype × timing interaction p = 0.0027
Control 10 dpi vs. DKO 10 dpi p = 0.9996
Control 20 dpi vs. DKO 20 dpi p = 0.0058
Control 120 dpi vs. DKO 120 dpi p = 0.0012
DKO 10 dpi vs. 20 dpi p = 0.0032
DKO 10 dpi vs. 120 dpi p = 0.0004
DKO 20 dpi vs. 120 dpi p = 0.6551
af 3T, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: NaV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.3498
Genotype × timing interaction p = 0.3510
Control 10 dpi vs. DKO 10 dpi p = 0.0085
Control 20 dpi vs. DKO 20 dpi p = 0.0018
Control 30 dpi vs. DKO 30 dpi p = 0.0003
DKO 10 dpi vs. 20 dpi p = 0.9713
DKO 10 dpi vs. 30 dpi p = 0.2965
DKO 20 dpi vs. 30 dpi p = 0.7138
ag 3T, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: NaV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0451
Genotype × timing interaction p = 0.0452
Control 10 dpi vs. DKO 10 dpi p = 0.4863
Control 20 dpi vs. DKO 20 dpi p = 0.0089
Control 60 dpi vs. DKO 60 dpi p = 0.0004
DKO 10 dpi vs. 20 dpi p = 0.2164
DKO 10 dpi vs. 60 dpi p = 0.0152
DKO 20 dpi vs. 60 dpi p = 0.8617
ah 3T, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: NaV intensity
Effect of genotype p = 0.0015
Effect of timing postinjection p = 0.0108
Genotype × timing interaction p = 0.0107
Control 10 dpi vs. DKO 10 dpi p = 0.9987
Control 20 dpi vs. DKO 20 dpi p = 0.7937
Control 120 dpi vs. DKO 120 dpi p = 0.0025
DKO 10 dpi vs. 20 dpi p = 0.9066
DKO 10 dpi vs. 120 dpi p = 0.0026
DKO 20 dpi vs. 120 dpi p = 0.0259
ai 3U Normal distribution Unpaired, two-tailed t test SC- NaV: relative protein level
Control vs. P13 ablation DKO p = 0.8532
Control vs. P23 ablation DKO p = 0.927
Control vs. P93 ablation p = 0.98
aj 4S, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: BIV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0169
Genotype × timing interaction p = 0.0170
Control 10 dpi vs. DKO 10 dpi p = 0.1170
Control 20 dpi vs. DKO 20 dpi p = 0.0017
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.1209
DKO 10 dpi vs. 30 dpi p = 0.0036
DKO 20 dpi vs. 30 dpi p = 0.6801
ak 4S, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: BIV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0423
Genotype × timing interaction p = 0.0425
Control 10 dpi vs. DKO 10 dpi p = 0.7035
Control 20 dpi vs. DKO 20 dpi p = 0.1771
Control 60 dpi vs. DKO 60 dpi p = 0.0006
DKO 10 dpi vs. 20 dpi p = 0.9089
DKO 10 dpi vs. 60 dpi p = 0.0215
DKO 20 dpi vs. 60 dpi p = 0.1587
al 4S, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: BIV intensity
Effect of genotype p = 0.0006
Effect of timing postinjection p = 0.0394
Genotype × timing interaction p = 0.0394
Control 10 dpi vs. DKO 10 dpi p = 0.9642
Control 20 dpi vs. DKO 20 dpi p = 0.2846
Control 120 dpi vs. DKO 120 dpi p = 0.0040
DKO 10 dpi vs. 20 dpi p = 0.6927
DKO 10 dpi vs. 120 dpi p = 0.0147
DKO 20 dpi vs. 120 dpi p = 0.1642
am 4T, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: BIV intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.2569
Genotype × timing interaction p = 0.2569
Control 10 dpi vs. DKO 10 dpi p = 0.0004
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.9939
DKO 10 dpi vs. 30 dpi p = 0.2390
DKO 20 dpi vs. 30 dpi p = 0.5023
an 4T, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: BIV intensity
Effect of genotype p = 0.0003
Effect of timing postinjection p = 0.1459
Genotype × timing interaction p = 0.1459
Control 10 dpi vs. DKO 10 dpi p = 0.8248
Control 20 dpi vs. DKO 20 dpi p = 0.1930
Control 60 dpi vs. DKO 60 dpi p = 0.0043
DKO 10 dpi vs. 20 dpi p = 0.8728
DKO 10 dpi vs. 60 dpi p = 0.0925
DKO 20 dpi vs. 60 dpi p = 0.5341
ao 4T, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: BIV intensity
Effect of genotype p = 0.0198
Effect of timing postinjection p = 0.0050
Genotype × timing interaction p = 0.0050
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi p = 0.9978
Control 120 dpi vs. DKO 120 dpi p = 0.0042
DKO 10 dpi vs. 20 dpi p = 0.9877
DKO 10 dpi vs. 120 dpi p = 0.0031
DKO 20 dpi vs. 120 dpi p = 0.0019
ap 4U Normal distribution Unpaired, two-tailed t test SC- BIV: relative protein level
Control vs. P13 ablation DKO p = 0.7971
Control vs. P23 ablation DKO p = 0.9601
Control vs. P93 ablation p = 0.8546
aq 5S, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P13 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0001
Genotype × timing interaction p = 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.0005
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p > 0.9999
DKO 10 dpi vs. 20 dpi p = 0.0926
DKO 10 dpi vs. 30 dpi p = 0.0009
DKO 20 dpi vs. 30 dpi p < 0.0001
ar 5S, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P23 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p < 0.0001
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 60 dpi vs. DKO 60 dpi p = 0.8245
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 60 dpi p < 0.0001
DKO 20 dpi vs. 60 dpi p < 0.0001
as 5S, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SN P93 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.0008
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 120 dpi vs. DKO 120 dpi p = 0.1776
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 120 dpi p < 0.0001
DKO 20 dpi vs. 120 dpi p < 0.0001
at 5T, P13 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P13 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0002
Genotype × timing interaction p < 0.0003
Control 10 dpi vs. DKO 10 dpi p = 0.3295
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p = 0.9979
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 30 dpi p = 0.4570
DKO 20 dpi vs. 30 dpi p < 0.0001
au 5T, P23 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P23 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.8577
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 60 dpi vs. DKO 60 dpi p > 0.9999
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 60 dpi p = 0.8179
DKO 20 dpi vs. 60 dpi p < 0.0001
av 5T, P93 Normal distribution Two-way ANOVA; Tukey post hoc analysis SC P93 ablation: AnkR intensity
Effect of genotype p < 0.0001
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.8502
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 120 dpi vs. DKO 120 dpi p = 0.4611
DKO 10 dpi vs. 20 dpi p < 0.0001
DKO 10 dpi vs. 120 dpi p = 0.9796
DKO 20 dpi vs. 120 dpi p < 0.0001
aw 5U Normal distribution Unpaired, two-tailed t test SC- AnkR: relative protein level
Control vs. P13 ablation DKO p = 0.9677
Control vs. P23 ablation DKO p = 0.4293
Control vs. P93 ablation p = 0.2763
ax 6B Normal distribution Two-way ANOVA; Tukey post hoc analysis P13 ablation: NCV
Effect of genotype p = 0.0927
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p < 0.0001
Control 10 dpi vs. DKO 10 dpi p = 0.0005
Control 20 dpi vs. DKO 20 dpi p < 0.0001
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.7586
DKO 10 dpi vs. 30 dpi p = 0.2018
DKO 20 dpi vs. 30 dpi p = 0.9264
ay 6C Normal distribution Two-way ANOVA; Tukey post hoc analysis P13 ablation: Notch Amp
Effect of genotype p = 0.0006
Effect of timing postinjection p < 0.0001
Genotype × timing interaction p = 0.0016
Control 10 dpi vs. DKO 10 dpi p = 0.9992
Control 20 dpi vs. DKO 20 dpi p = 0.3675
Control 30 dpi vs. DKO 30 dpi p < 0.0001
DKO 10 dpi vs. 20 dpi p = 0.7221
DKO 10 dpi vs. 30 dpi p = 0.9993
DKO 20 dpi vs. 30 dpi p = 0.4799
az 6E Normal distribution Two-way ANOVA; Tukey post hoc analysis P23 ablation: NCV
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.0428
Genotype × timing interaction p = 0.0171
Control 10 dpi vs. DKO 10 dpi p > 0.9999
Control 20 dpi vs. DKO 20 dpi 0.0021
Control 60 dpi vs. DKO 60 dpi 0.0004
DKO 10 dpi vs. 20 dpi p > 0.9999
DKO 10 dpi vs. 60 dpi p = 0.9991
DKO 20 dpi vs. 60 dpi p = 0.9998
ba 6F Normal distribution Two-way ANOVA; Tukey post hoc analysis P23 ablation: Notch Amp
Effect of genotype p = 0.0007
Effect of timing postinjection p = 0.5107
Genotype × timing interaction p = 0.4310
Control 10 dpi vs. DKO 10 dpi p = 0.9582
Control 20 dpi vs. DKO 20 dpi p = 0.0492
Control 60 dpi vs. DKO 60 dpi p = 0.034
DKO 10 dpi vs. 20 dpi p = 0.6092
DKO 10 dpi vs. 60 dpi p = 0.8662
DKO 20 dpi vs. 60 dpi p = 0.9906
bb 6H Normal distribution Two-way ANOVA; Tukey post hoc analysis P93 ablation: NCV
Effect of genotype p < 0.0001
Effect of timing postinjection p = 0.9269
Genotype × timing interaction p = 0.0770
Control 20 dpi vs. DKO 20 dpi p = 0.8318
Control 60 dpi vs. DKO 60 dpi p = 0.0002
Control 120 dpi vs. DKO 120 dpi p = 0.0644
DKO 20 dpi vs. 60 dpi p = 0.9163
DKO 20 dpi vs. 120 dpi p = 0.4341
DKO 60 dpi vs. 120 dpi p = 0.9652
bc 6I Normal distribution Two-way ANOVA; Tukey post hoc analysis P93 ablation: Notch Amp
Effect of genotype p = 0.0213
Effect of timing postinjection p = 0.0088
Genotype × timing interaction p = 0.0174
Control 20 dpi vs. DKO 20 dpi p > 0.9999
Control 60 dpi vs. DKO 60 dpi p = 0.0713
Control 120 dpi vs. DKO 120 dpi p = 0.0041
DKO 20 dpi vs. 60 dpi p > 0.9999
DKO 20 dpi vs. 120 dpi p = 0.3463
DKO 60 dpi vs. 120 dpi p = 0.4148

Note: GraphPad Prism, which was used to perform all statistical analyses, does not report exact p-values higher than 0.9999 or lower than 0.0001.

All statistical tests are summarized with exact p-values.