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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Hippocampus. 2018 May 4;28(7):512–522. doi: 10.1002/hipo.22950

Figure 1.

Figure 1

Sucrose reward operant training and progressive ratio testing in GFAP-TK rats and mice with and without valganciclovir treatment. Experimental timeline for rats showing valganciclovir (vgcv) treatment and testing (A). Rats lacking adult neurogenesis (TK rats) showed no difference relative to their wild type (WT) counterparts in the number of sucrose rewards earned during training on an increasing fixed ratio (FR) schedule (B), but they showed a significantly lower breakpoint for sucrose rewards under a progressive ratio (C). Experimental timeline showing vgcv treatment and testing in mice (D). TK mice showed no difference from WT mice in the time to earn 50 rewards under an increasing FR schedule (E) but, like rats, showed a lower breakpoint under a progressive ratio (F). Experimental timeline in a control experiment without vgcv (G). Untreated WT and TK rats showed normal learning on FR schedule (H) and a normal breakpoint (I). n=7-10/genotype. * P<0.05 main effect of genotype. Data are means ±SEM.