Table 3.

Study 2b Multivariable Proportional Hazard model of time to reach Montreal Cognitive Assessment Score of ≤20.

Overall Model Likelihood Ratio Chi square = 22.70, p<0.0001, 3 degrees of freedom
Covariates	Hazard Ratio	Standard Error	Z-score	p-value	95% Confidence Interval for Hazard Ratio
Mean bilateral caudate DaT SPECT binding ratio at screening	0.456	0.183	−1.96	0.050	0.208,1.000
Serotoninergic medication status at baseline	0.223	0.165	−2.03	0.043	0.052, 0.952
Mean baseline Aβ-42 (pg/ml)	0.993	0.002	−3.25	0.001	0.989, 0.997