Table 3.

Clinical Ratings from Patient 1. Bradykinesia score is derived from items 23a-25b of the UPDRS and Dyskinesia score is derived from the UDYS rating scale. In both cases, scores were summed and then averaged across time. We have reported rating scales which are both bilateral and unilateral (reflecting the side of the body contralateral to the side modulated by adaptive DBS.) Note that for the dyskinesia rating scale the highest theoretical score is 28, so patient’s overall dyskinesia was relatively low, suggesting that a floor effect could be occurring.

Stimulation mode	Bradykinesia Score Total/Contralateral only	Dyskinesia Score Total/Contralateral only	Total Energy Saved Relative to Open-loop	Minutes Since Last Medication Dose (session start-session end)
Adaptive, Nexus D3	14/7	1.5/1.25	38%	110-175
Adaptive, Nexus E	11.83/4.67	1.33/1.33	45%	65-110
Open-loop	12.33/5.67	1.667/1.33	0%	70-110