Table 3.
Proteins detected in at least 7 of the total of 14 proteomics analyses and that differed significantly (P<0.05) in abundance by a factor ⩾ 1.5 between pre- and post-pioglitazone treatment
| Protein name (gene name) | Fold change | Student’s t-test | Wilcoxon signed-rank test |
|---|---|---|---|
|
| |||
| P-value | P-value | ||
| Up-regulated proteins | |||
| Collagen, type VI, alpha-3 (COL6A3) | 4.71 | = 0.146 | <0.044 |
| Cytochrome b–c1 complex subunit 8 (UQCRQ) | 4.66 | <0.004 | <0.028 |
| Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) | 4.12 | = 0.054 | <0.028 |
| Protein NipSnap homolog 3 A (NIPSNAP3A) | 3.95 | <0.037 | <0.044 |
| Signal recognition particle receptor subunit beta (SRPRB) | 2.37 | <0.048 | <0.047 |
| Membrane metallo-endopeptidase (MME) | 2.27 | <0.045 | <0.044 |
| Isoform 1 of Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) | 2.20 | <0.016 | <0.028 |
| Isoform 2 of Leucyl-cystinyl aminopeptidase (LNPEP) | 2.19 | <0.011 | <0.028 |
| Isoform 2C2 of Collagen alpha-2(VI) chain (COL6A2) | 2.07 | = 0.143 | <0.028 |
| Apolipoprotein O-like (APOOL) | 2.01 | <0.021 | <0.028 |
| ATP synthase subunit b, mitochondrial (ATP5F1) | 1.87 | <0.002 | <0.018 |
| 40S ribosomal protein S3a (RPS3A) | 1.81 | = 0.095 | <0.044 |
| Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic isoform a (CMPK1) | 1.74 | = 0.070 | <0.028 |
| Nucleoside diphosphate kinase 3 (NME3) | 1.68 | <0.041 | <0.028 |
| Isoform 1 of Enoyl-CoA hydratase domain-containing protein 1 (ECHDC1) | 1.63 | <0.008 | <0.018 |
| Prohibitin (PHB) | 1.60 | = 0.054 | <0.043 |
| Mitochondrial carrier homolog 2 (MTCH2) | 1.60 | <0.006 | <0.018 |
| Aspartyl-tRNA synthetase, cytoplasmic (DARS) | 1.58 | = 0.193 | <0.044 |
| Activated RNA polymerase II transcriptional coactivator p15 (SUB1) | 1.57 | = 0.066 | <0.044 |
| Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) | 1.56 | <0.065 | <0.028 |
| Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) | 1.55 | <0.021 | <0.028 |
| Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) | 1.55 | <0.039 | <0.047 |
| Downregulated proteins | |||
| Isoform 1 of Myosin-10 (MYH10) | 0.66 | <0.002 | <0.018 |
| Tubulin beta-2A chain (TUBB2A) | 0.64 | <0.001 | <0.018 |
| Ferritin (FTL) | 0.63 | <0.011 | <0.028 |
| 60S ribosomal protein L30 (RPL30) | 0.61 | <0.009 | <0.047 |
| Transmembrane protein 43 (TMEM43) | 0.61 | <0.009 | <0.018 |
| Transmembrane protein 109 (TMEM109) | 0.60 | = 0.156 | <0.044 |
| Isoform Long of Ubiquitin carboxyl-terminal hydrolase 5 (USP5) | 0.57 | <0.021 | <0.047 |
| PRA1 family protein 3 (ARL6IP5) | 0.56 | = 0.196 | <0.028 |
| Isoform Short of Adenosine kinase (ADK) | 0.54 | = 0.135 | <0.044 |
| Sideroflexin 3 (SFXN3) | 0.53 | <0.017 | <0.044 |
| Peflin (PEF1) | 0.52 | = 0.063 | <0.044 |
| General vesicular transport factor p115 (USO1) | 0.50 | = 0.104 | <0.044 |
| Dolichol-phosphate mannosyltransferase subunit 1 (DPM1) | 0.49 | <0.058 | <0.044 |
| Isoform 1 of Spectrin Alpha Chain, Non-Erythrocytic 1 (SPTAN1) | 0.42 | <0.043 | <0.047 |
| Protein NOXP20 (FAM114A1) | 0.38 | <0.036 | <0.044 |
| Prolow-density lipoprotein receptor-related protein 1 (LRP1) | 0.36 | <0.006 | <0.028 |
| Hsp90 co-chaperone Cdc37 (CDC37) | 0.22 | = 0.120 | <0.047 |
| Long-chain fatty acid–CoA ligase 3 (ACSL3) | 0.22 | <0.048 | <0.044 |