Table 1.
Characteristics of SCA patients and 789 transfusion episodes.
Comparison of patients without past RBC antibodies vs. those with past RBC alloantibodies or autoantibodies.
| No RBC Antibodies (Category 1 Matching) | RBC Antibodies (Category 2 Matching) | p | |
|---|---|---|---|
| Patients | N=36 (36%) | N=24 (40%) | |
| Age (years), mean (SD) | 10.2 (3.8) | 12.5 (3.3) | 0.017 |
| Gender, male | 19 (53%) | 12 (50%) | 0.83 |
| CTT duration (years), mean (SD) | 4.7 (3.2) | 5.8 (3.5) | 0.22 |
| Splenectomy (%) | 7 (19.4%) | 5 (25.0%) | 0.61 |
| Splenomegaly (%) | 1 (2.8%) | 1 (4.2%) | 1.00 |
| Transfusions | N=488 | N=301 | |
| Antibody Screen positive (%) | 0 (0%) | 25 (8.3%) | – |
| Mean age of units per transfusion (days), LS-mean (SE) | 20.5 (0.59) | 17.6 (0.74) | 0.0018 |
| Volume of transfusion (mL/kg), LS-mean (SE) | 12.7 (0.25) | 13.1 (0.32) | 0.31 |
| Transfusion interval (days), LS-mean (SE) | 29.9 (0.55) | 29.2 (0.69) | 0.38 |
| Pre-transfusion Laboratory Values | |||
| Hb (g/dL), LS-mean (SE) | 9.35 (0.12) | 9.36 (0.14) | 0.97 |
| HbS (%), LS-mean (SE) | 23.5 (1.4) | 23.8 (1.7) | 0.84 |
| Reticulocytes (%), LS-mean (SE) | 9.9 (0.58) | 10.6 (0.70) | 0.35 |
| Reticulocytes, absolute (10^9/L), LS-mean (SE) | 309.8 (15.5) | 325.8 (18.9) | 0.47 |
CTT = chronic transfusion therapy; Hb = hemoglobin; HbS = sickle hemoglobin; LS-mean = least-squares mean; PME = partial manual exchange transfusion; SD = standard deviation; SE = standard error; ST = simple transfusion.