Table 3.

Association between serum levels of LDL and HDL and prostate cancer risk at the 2-year biopsy in REDUCE

	Overall prostate cancer risk		Low-grade prostate cancer		High-grade prostate cancer
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
LDL†
Unadjusted
Normal	1.00 (Ref)	–	1.00 (Ref)	–	1.00 (Ref)	–
Borderline	1.05 (0.80–1.37)	0.723	1.23 (0.88–1.71)	0.229	0.77 (0.51–1.18)	0.233
High	0.92 (0.68–1.24)	0.567	1.05 (0.73–1.51)	0.809	0.71 (0.44–1.15)	0.165
Per 10 mg/dl	0.99 (0.97–1.02)	0.451	1.00 (0.97–1.02)	0.749	0.98 (0.94–1.02)	0.345
Adjusted*
Normal	1.00 (Ref)	–	1.00 (Ref)	–	1.00 (Ref)	–
Borderline	1.04 (0.79–1.37)	0.769	1.19 (0.85–1.66)	0.311	0.80 (0.52–1.24)	0.326
High	0.86 (0.63–1.18)	0.347	0.97 (0.67–1.42)	0.886	0.68 (0.42–1.13)	0.137
Per 10 mg/dl	0.98 (0.96–1.01)	0.218	0.99 (0.96–1.02)	0.433	0.98 (0.93–1.02)	0.260
HDL††
Unadjusted
Low	1.00 (Ref)	–	1.00 (Ref)	–	1.00 (Ref)	–
Borderline	1.20 (0.96–1.50)	0.106	1.17 (0.90–1.51)	0.235	1.28 (0.86–1.90)	0.219
Normal	1.30 (0.99–1.69)	0.055	1.24 (0.91–1.70)	0.167	1.43 (0.90–2.28)	0.130
Per 10 mg/dl	1.10 (1.03–1.17)	0.004	1.08 (1.00–1.17)	0.040	1.14 (1.02–1.27)	0.017
Adjusted*
Low	1.00 (Ref)	–	1.00 (Ref)	–	1.00 (Ref)	–
Borderline	1.17 (0.93–1.47)	0.176	1.12 (0.86–1.46)	0.397	1.31 (0.87–1.97)	0.197
Normal	1.19 (0.90–1.58)	0.215	1.12 (0.81–1.55)	0.490	1.39 (0.85–2.28)	0.190
Per 10 mg/dl	1.08 (1.01–1.16)	0.033	1.06 (0.97–1.14)	0.197	1.14 (1.01–1.28)	0.034

^*adjusted for age, race, geographic region, PSA, BMI, DRE, family history of prostate cancer, coronary artery disease, smoking status, diabetes, alcohol use, treatment group, total cholesterol level

^†LDL analysis additionally adjusted for HDL level

^††HDL analysis additionally adjusted for LDL level