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. 2018 Jun 12;9(45):27698–27707. doi: 10.18632/oncotarget.25498

Figure 4. Inhibition of PKM2 shows anti-tumor effect and improves resistance to mTOR inhibitor in C4-2AT6 cells.

Figure 4

(A) The expression of PKM2 was inhibited and the expression of cleaved PARP and cleaved caspase3 was up-regulated in C4-2AT6 under chronic hypoxia exposed to si-PKM2 for 24 hr. (B) The number of C4-2AT6 under chronic hypoxia exposed to siPKM2 after 72 hours significantly decreased compared to intact C4-2AT6 under chronic hypoxia. (C) The number of C4-2AT6 cells under hypoxia exposed to both 100nM RAD001 and si-PKM2 for 48 hours significantly decreased compared to C4-2AT6 cells expose to RAD001 only, while the number of C4-2AT6 cells under hypoxia exposed to RAD001 and mock showed no remarkable difference with C4-2AT6 cells exposed to RAD001.