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. 2018 Jun 12;9(45):27630–27644. doi: 10.18632/oncotarget.25250

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Copyright: © 2018 Schulz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Transcriptional profiles of various EMT related genes in response to the GSK3α/β inhibitor SB 216763. 84 different EMT related genes are shown in permanent HNSCC cell lines UT-SCC 16A/B (A and B) in response to SB 216763. Strongly increased mRNA levels of the EMT related genes BMP7, DSC2, GNG11, MMP3 as well as STEAP1 are illustrated. BMP7 as well as DSC2 are supposed to act as negative EMT regulators, whereas GNG11, MMP2 and STEAP1 are suggested to be activators.