Table 2.

Univariate and multivariate Cox analysis of clinical characteristics for prognosis of small intestine adenocarcinoma for 5 year CSS.

Characteristics	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age
<50	Reference		Reference
50–75	1.20 (0.96–1.51)	0.102	1.26 (1.01–1.58)	0.043
>75	1.83 (1.41–2.38)	<0.001	2.19 (1.67–2.86)	<0.001
Gender
Male	Reference
Female	0.91 (0.78–1.06)	0.240
Race
White	Reference
Black	0.98 (0.79–1.21)	0.845
Others	1.14 (0.84–1.54)	0.392
Location
Duodenum	Reference
Jejunum	0.89 (0.74–1.07)	0.219
Ileum	1.04 (0.85–1.26)	0.725
Small intestine, not specified	0.86 (0.43–1.73)	0.670
8th T stage
T1	Reference		Reference
T2	0.99 (0.34–2.90)	0.986	1.10 (0.38–3.22)	0.863
T3	2.57 (0.96–6.91)	0.061	2.07 (0.77–5.59)	0.149
T4	4.59 (1.71–12.30)	0.002	3.13 (1.16–8.41)	0.024
8th M stage
M0	Reference		Reference
M1	3.72 (3.11–4.44)	<0.001	3.72 (3.11–4.44)	<0.001
Grade
G1/G2	Reference		Reference
G3/G4	1.68 (1.44–1.97)	<0.001	1.40 (1.19–1.65)	<0.001
Histology
Conventional adenocarcinoma	Reference		Reference
Mucinous adenocarcinoma	1.00 (0.76–1.32)	0.978	1.02 (0.77–1.36)	0.854
Signet ring cell carcinoma	1.98 (1.39–2.81)	<0.001	1.09 (0.75–1.58)	0.638
Examined lymph nodes
≤16	Reference		Reference
>16	0.82 (0.69–0.97)	0.022	0.79 (0.66–0.94)	0.009
No. Positive lymph nodes
0	Reference		Reference
1–2	1.79 (1.46–2.21)	<0.001	1.40 (1.13–1.73)	0.002
3–8	2.95 (2.42–3.58)	<0.001	2.15 (1.75–2.64)	<0.001
>8	4.21 (3.12–5.69)	<0.001	2.72 (1.97–3.76)	<0.001
Tumor size
≤5 cm	Reference		Reference
>5 cm	0.74 (0.62–0.88)	<0.001	0.81 (0.67–0.97)	0.024

The number of examined lymph nodes was not included for the AIC is bigger after included it into nomogram, not the optimal model.