Fig. 2.
Effect of RGn500 treatment on Aβ25–35 (AB25–35)–induced deficits in the step-through latency (A and C) and the escape latency (B and D) in the passive avoidance task. Different times of exposure, the frequency (once a day [o.d.] or twice a day [b.i.d.]), and the mode of delivery with exposure of head alone (at 10 Hz), of abdomen alone (at 1000 Hz), or of both body parts (h/a) were examined. Data are presented as mean ± SEM. ***P < .001 versus Sc Aβ (Sc.AB) group; ##P < .01, ###P < .001 versus Aβ25–35 group. n = 12–21 per group. Abbreviations: Aβ25–35, amyloid β peptide 25–35; SEM, standard error of mean.