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. 2018 Jun 11;32:9–20. doi: 10.1016/j.ebiom.2018.05.035

Fig. 5.

Fig. 5

Age-related macular degeneration (AMD) patients have altered peripheral blood mononuclear cell (PBMC) and plasma oxysterol signatures. (a-j) We measured PBMC and plasma levels of 4β-HC, 7-KC, C-triol, 24-HC, and 27-HC. AMD patients (N = 44–45) had decreased PBMC 7-KC levels (b; 2-tailed Mann-Whitney U test), elevated plasma 4β-HC levels (f; 2-tailed Mann-Whitney U test), elevated plasma C-triol levels (h; 2-tailed Mann-Whitney U test), elevated plasma 24-HC levels (i; 2-tailed Mann-Whitney U test), and a trend towards elevated plasma 27-HC levels (j; 2-tailed, unpaired t-test) compared to non-AMD controls (N = 61). Open circles depict individual data points; horizontal lines depict mean ± 95% confidence intervals (a-j) (* P < .05; ** P < .01; *** P < .001).