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The pharmacokinetics of Compound 1 administration. 10.0 mg/kg of Compound 1 was administered by oral gavage at time 0. Plasma and BALF were collected simultaneously from separate cohorts of mice at 0.5, 1, 2, 4, 8, and 24 h after the dosing. The plasma concentration of drug over time (1A) and the BALF cAMP levels over time (1B) are reported. A linear relationship between plasma drug level and BALF cAMP concentration was observed (1C). Data are reported as mean ± SD (n = 4/group).
