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. 2018 Jun 27;6(12):e13753. doi: 10.14814/phy2.13753

Figure 6.

Figure 6

Prophylactic treatment of targeted type II AEC‐injured mice with Compound 1 reduces plasma SP‐D levels. DTR‐expressing mice (DTR+) were administered daily I.P. PBS or DT from day 0 through Day 14. Subsets of the DTR+:DT‐treated animals were treated by oral gavage once daily beginning on day 0 with vehicle, Compound 1 (1.0 mg/kg, 5.0 mg/kg, or 10.0 mg/kg) or Piclamilast at 30 mg/kg. Plasma was collected on day 21 and analyzed for SP‐D concentration (A). The plasma SP‐D concentration was then correlated with lung collagen content (B). Data are reported as mean + SEM with individual data points shown (n = 8 per group). # P ≤ 0.05 versus Vehicle group by two‐tailed Williams’ test. $ P ≤ 0.05 versus Vehicle group by Student's t‐test.