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. 2018 May 24;32:84–92. doi: 10.1016/j.ebiom.2018.05.008

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Expression of PGE₂ receptors in human and murine tumors. (a) Immunohistochemical staining of EP1-EP4 (DAB, brown staining) in primary human high-risk neuroblastoma tumors: MYCN-amplified and 11q-deleted (11q-), respectively. (b) Immunohistochemical analysis of EP1-EP4 in tumors from two different mouse models of neuroblastoma: a transgenic MYCN-driven model (tgTH-MYCN) and a xenograft model inoculated with the 11q-deleted human neuroblastoma cell line SK-N-AS (SK-N-AS xenograft). Sections were counterstained with Mayer's hematoxylin. Scale bars indicate 50 μm. (c) Dual labeling of PGE₂ receptors, EP3 and EP4 (green), with neuroblastoma marker GD2 and CAF marker PDGFRβ (red) respectively in primary human neuroblastoma tumors. Sections were counterstained with nuclear dye Hoechst (blue).