Table 2. Differences in Clinical and Genetic Features between LADA and T2DM.

	LADA	T2DM
Age at diagnosis	>30 Years	Adulthood (rarely before)
Family history of diabetes	Negative or positive	Frequently positive
HLA susceptibility	Increased	Mild increased
Onset	Subclinical (rarely acute)	Silent/subclinical
Rate of long-term complications at diagnosis	Low	High
Risk of acute complications at diagnosis	Low	Mild increased
C-peptide levels at diagnosis	Decreased but still detectable	Normal to increased
Autoimmunity	Mild increased	Absent
Ketosis	Rare	Rare
Insulin resistance	Increased/no change	Increased
β-Cell function	Decreased	Increased or normal
Insulin requirement	>6 Months after diagnosis	Absent or years after diagnosis
Body mass index	Normal (rarely overweight or obese)	Overweight or obese
Cardiovascular risk	Increased	Increased
Lipid profile	Normal to hypertriglyceridemia	Frequently hypertriglyceridemia and/or hypercholesterolemia

LADA, latent autoimmune diabetes in adults; T2DM, type 2 diabetes mellitus; HLA, human leukocyte antigen.