Table 3. Differences in Clinical and Genetic Features between LADA and T1DM.

	LADA	T1DM
Age at diagnosis	>30 Years	Childhood/adolescence (rarely in adulthood)
Family history of diabetes	Negative or positive	Negative or positive
HLA susceptibility	Increased	Importantly increased
Onset	Subclinical (rarely acute)	Acute
Rate of long-term complications at diagnosis	Low	Low
Risk of acute complications at diagnosis	Low	Increased
C-peptide levels at diagnosis	Decreased but still detectable	Non detectable (rarely decreased)
Autoimmunity	Mild increased	Importantly increased
Ketosis	Rare	Rare
Insulin resistance	Mild increased	Absent (rarely increased)
β-Cell function	Decreased (−)	Loss of function
Insulin requirement	>6 Months after diagnosis	At diagnosis
Body mass index	Normal (rarely overweight or obese)	Normal (or underweight)
Cardiovascular risk	Increased	Increased
Lipid profile	Normal to hypertriglyceridemia	Normal (especially)

LADA, latent autoimmune diabetes in adults; T1DM, type 1 diabetes mellitus; HLA, human leukocyte antigen.