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. 2018 Jun 15;9(46):28042–28068. doi: 10.18632/oncotarget.25556

Figure 3. Apoptosis and modulation of cell signalling in A2780 cell line.

Figure 3

(A) Percentage of apoptotic cells shown by flow cytometry analysis of annexin V/propidium iodide-stained A2780 cells treated for 72 h with Au(NHC) and Au(NHC)2 -72 h-exposure IC50-dose. (B) Caspase-8, (C) Caspase-9 and (D) Caspase-3 activity shown by fluorescence-activated cell sorting analysis using FAM FLICA in A2780 cells treated for 72 h with Au(NHC) and Au(NHC)2 concentration corresponding to their 72 h-exposure IC50-dose. Flow cytometric images are representative of three independent experiments. Histograms report the mean values ±SD. The statistical analysis was carried out using one-way ANOVA test followed by Tuckey's multiple comparisons test using Graphpad Prism v 6.0 (*p<0.05, **p<0.01, ***p<0.001).