Table 3. Overrepresentation Enrichment Analysis (ORA) of GO terms and pathways obtained from the identified protein list, using Webgestalt functional enrichment analysis web tool.

Gene set	Description	Ca	Ob	Ec	Rd	p-valuee	FDRf
Biological Process
GO:0010608	posttranscriptional regulation of gene expression	454	10	1.35	7.40	6.29E-07	4.79E-04
GO:0034248	regulation of cellular amide metabolic process	359	8	1.07	7.49	9.00E-06	3.43E-03
GO:0071897	DNA biosynthetic process	194	6	0.58	10.4	2.17E-05	5.52E-03
GO:0009123	nucleoside monophosphate metabolic process	308	7	0.92	7.64	3.09E-05	5.89E-03
GO:0006091	generation of precursor metabolites and energy	365	7	1.09	6.44	9.04E-05	1.38E-02
GO:0046939	nucleotide phosphorylation	90	4	0.27	14.9	1.44E-04	1.83E-02
GO:0009141	nucleoside triphosphate metabolic process	290	6	0.86	6.95	2.01E-04	2.08E-02
GO:1901657	glycosyl compound metabolic process	421	7	1.25	5.58	2.19E-04	2.08E-02
GO:0009132	nucleoside diphosphate metabolic process	109	4	0.32	12.3	3.01E-04	2.55E-02
GO:0060249	anatomical structure homeostasis	341	6	1.02	5.91	4.80E-04	3.66E-02
Molecular Function
GO:0098631	protein binding involved in cell adhesion	293	7	0.99	7.00	5.27E-05	1.26E-02
GO:0050839	cell adhesion molecule binding	445	8	1.52	5.27	1.08E-04	1.26E-02
GO:0042162	telomeric DNA binding	30	3	0.10	29.3	1.40E-04	1.26E-02
GO:0051082	unfolded protein binding	105	4	0.36	11.2	4.35E-04	2.92E-02
GO:0003727	single-stranded RNA binding	70	3	0.24	12.6	1.72E-03	9.08E-02
GO:0017025	TBP-class protein binding	21	2	0.07	27.9	2.29E-03	9.08E-02
GO:0003729	mRNA binding	170	4	0.58	6.89	2.60E-03	9.08E-02
GO:0044389	ubiquitin-like protein ligase binding	285	5	0.97	5.14	2.70E-03	9.08E-02
GO:0042287	MHC protein binding	25	2	0.08	23.4	3.24E-03	9.43E-02
GO:0036002	pre-mRNA binding	26	2	0.08	22.5	3.51E-03	9.43E-02
Cellular Component
GO:0043209	myelin sheath	165	7	0.62	11.3	2.11E-06	3.12E-04
GO:0005759	mitochondrial matrix	423	8	1.59	5.04	1.33E-04	7.27E-03
GO:0005913	cell-cell adherens junction	318	7	1.19	5.87	1.47E-04	7.28E-03
GO:0009295	nucleoid	45	3	0.17	17.8	6.16E-04	2.28E-02
GO:0005681	spliceosomal complex	173	4	0.65	6.16	3.81E-03	1.00E-01
Pathways (KEGG database)
hsa01200	Carbon metabolism	114	5	0.49	10.2	1.13E-04	3.43E-02
hsa01230	Biosynthesis of amino acids	75	4	0.32	12.3	2.80E-04	4.24E-02
Pathways (Panther database)
P00024	Glycolysis	17	3	0.08	36.5	5.50E-05	6.22E-03

^a The number of reference genes in the category

^b The number of genes in the user gene list and also in the category

^c The expected number in the category

^d Ratio of enrichment

^e p-value from hyergeometric test

^f FDR from Benjamini and Hochberg (BH).