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. 2018 Jun 15;9(46):28103–28115. doi: 10.18632/oncotarget.25563

Figure 1. Relative expression of miR-519d and miR-4758 in GNTs and astrocytomas.

Figure 1

Quantitative real-time PCR. Panels (A and B): Relative expression of miR-519d (A) and miR-4758 (B) in GG (n=14), PA (n=15), AII (n=10), AIII (n=14) and GB (n=15). Data are expressed relative to the expression in control cortex (n=7; frozen material). Panels (C and D): Expression of miR-519d (C) and miR-4758 (D) in peritumoural GG (n=7), GG (n=14), DNT (n=9) and SEGA (n=10); FFPE. Data are expressed relative to the expression in control cortex (n=9). miRNA expression was normalized to that of the U6B small nuclear RNA gene (Rnu6B) in all cohorts. Dots represent individual samples. The error bars represent SEM. *p < 0.05; **p < 0.01, ***p < 0.001 between experimental samples, Kruskal-Wallis test followed by Mann-Whitney U test; #p < 0.05 between GG and control cortex, Mann-Whitney U test. ctx: control cortex; GG: ganglioglioma; PA: pilocytic astrocytoma; AII: astrocytoma grade II; AIII: astrocytoma grade III; GB: glioblastoma; DNT: dysembryoplastic neuroepithelial tumour; SEGA: subependymal giant cell astrocytoma.