Table 1. Summary of clinical findings of glioneuronal tumours (GNTs).
| Patient | Diagnose | Gender | Localization | Age of surgery (years) | Age of seizure onset (years) | Duration of epilepsy (years) | Pre-operative seizure frequency (per month) | Post-operative outcome (Engel's score) | Mutation |
|---|---|---|---|---|---|---|---|---|---|
| 1a,c | GG | F | T | 29 | 13 | 16 | 200 | 1 | BRAF V600E |
| 2a,c | GG | F | T | 11 | 8 | 3 | 56 | 1 | BRAF V600E |
| 3a,c | GG | M | T | 16 | 14 | 2 | 30 | 1 | BRAF V600E |
| 4a,c | GG | F | T | 42 | 11 | 31 | 60 | 1 | NMI |
| 5a,b,c | GG | M | T | 21 | 13 | 8 | 70 | 2 | BRAF V600E |
| 6a,c | GG | F | T | 14 | 11 | 3 | 55 | 1 | BRAF T559R and BRAF V600E* |
| 7a,b | GG | F | P | 24 | 24 | 0 | 3 | 1 | BRAF V600E |
| 8a,c | GG | F | T | 23 | 14 | 9 | 60 | 1 | BRAF V600E |
| 9a | GG | F | T | 19 | 15 | 4 | 70 | 1 | NMI |
| 10a | GG | M | T | 18 | 13 | 5 | 20 | 1 | BRAF V600E |
| 11a,b | GG | M | P | 28 | 28 | 0 | 80 | 1 | BRAF V600E |
| 12a | GG | F | T | 34 | 11 | 23 | 90 | 1 | NMI |
| 13a | GG | M | T | 20 | 11 | 9 | 160 | 1 | BRAF V600E |
| 14a | GG | F | T | 49 | 19 | 30 | 150 | 1 | BRAF V600E |
| 15b | GG | F | T | 28 | 12 | 16 | 30 | 2 | BRAF V600E |
| 16b | GG | M | T | 10 | 9 | 1 | 30 | 1 | BRAF V600E |
| 17b | GG | M | T | 18 | 17 | 1 | <5 | 1 | NMI |
| 18b | GG | M | T | 44 | 20 | 24 | 10 | 1 | NMI |
| 19b | GG | F | T | 6 | 3 | 3 | 10-20 | 1 | NMI |
| 20b | GG | M | P | 42 | 1 | 41 | >30 | 1 | NMI |
| 21b | GG | F | B | 29 | No seizures | -- | -- | -- | NMI |
| 22b | GG | M | T | 33 | 18 | 15 | -- | 1 | NMI |
| 23b | GG | F | T | 22 | 10 | 12 | -- | 1 | NMI |
| 24b | GG | F | C | 48 | No seizures | -- | -- | -- | BRAF V600E |
| 25b | GG | M | T | 34 | 16 | 22 | <5 | 1 | BRAF V600E |
| 26b | GG | F | T | 56 | 52 | 4 | 80-100 | 2 | BRAF V600E |
| 27a | DNT | F | T | 15 | 11 | 4 | >50 | 1 | NMI |
| 28a | DNT | M | T | 41 | 19 | 22 | <5 | 1 | NMI |
| 29a | DNT | M | T | 11 | 10 | 1 | 10-20 | 1 | Mutation unknown |
| 30a | DNT | M | T | 8 | 2 | 6 | >30 | 1 | NMI |
| 31a | DNT | F | T | 30 | 25 | 5 | 5-10 | 4 | BRAF V600E |
| 32a | DNT | F | F | 11 | 8 | 3 | 10-20 | 1 | CIC G935R |
| 33a | DNT | F | T | 16 | 14 | 2 | <5 | 1 | NMI |
| 34a | DNT | M | T | 35 | 17 | 18 | >30 | 1 | FGFR1 G539R and FGFR1 K656E |
| 35a | DNT | F | T | 15 | 5 | 10 | >50 | 1 | NMI |
M male, F female, F frontal, T temporal, P parietal, B brainstem, C cerebellum, NMI no mutation identified; aFFPE (formalin-fixed, paraffin-embedded) tissue; bFrozen tissue; cPeritumoural cortex tissue. Gangliogliomas (GG) and dysembryoplastic neuroepithelial tumours (DNT). *Both mutations are on the same allel.