Table 1. Clinicopathological characteristics according to histologic subtypes of PTC.
| Characteristics | Classical (n = 1,374) | Follicular variant (n = 22) | Diffuse sclerosing variant (n = 10) | Tall cell variant (n = 5) |
|---|---|---|---|---|
| Age, yr | 50.0 ± 11.2 | 53.8 ± 9.6 | 43.7 ± 15.1a,b | 53.0 ± 21.7c |
| Sex, female | 1,234 (89.8) | 16 (72.7) | 7 (70.0)a | 3 (60.0)a |
| Tumor size, cm | 0.9 ± 0.6 | 1.4 ± 1.3a | 2.1 ± 1.2a,b | 2.0 ± 1.1a,b |
| ETE | 520 (37.8) | 7 (31.8) | 8 (80.0)a,b | 3 (60.0)a,b |
| LNM | 518 (37.7) | 4 (18.2)a | 9 (90.0)a,b | 3 (60.0)a,b |
| Advanced stage | 393 (28.6) | 9 (40.9) | 9 (90.0)a,b | 4 (80.0)a,b |
| BRAFV600E mutation | 850 (61.9) | 6 (27.3)a | 2 (20.0)a | 3 (60.0)b,c |
Statistical significance was tested by the χ2 test. Data are expressed as mean ± standard deviation and frequency (%) for categorical variables.
PTC = papillary thyroid carcinoma, ETE = extrathyroidal extension, LNM = lymph node metastasis, Advanced stage = American Joint Committee on Cancer (AJCC) stage III + IV.
aP < 0.05 vs. conventional PTC; bP < 0.05 vs. follicular variant PTC; cP < 0.05 vs. diffuse sclerosing variant PTC.