. 2018 May 23;33(27):e182. doi: 10.3346/jkms.2018.33.e182

Table 3. Changes in mean and standard deviation of HR, SBP, and DBP over time between single (day 1) and multiple dosing (day 8) for baseline (day 0).

Time, hr		Day 1–Day 0			Day 8–Day 0
Time, hr		EM (n = 6)	IM_1 (n = 7)	IM_2 (n = 8)	EM (n = 6)	IM_1 (n = 7)	IM_2 (n = 8)
HR
	1	3.15 ± 9.14	−1.63 ± 9.16	−0.38 ± 7.50	−3.17 ± 5.58	−3.86 ± 9.51	−4.25 ± 10.01
	2	2.29 ± 8.19	−5.75 ± 4.26	−0.75 ± 6.67	−0.84 ± 2.97^a	−6.58 ± 3.54^a	−1.25 ± 6.14^a
	3	−4.58 ± 4.98	−6.50 ± 7.87	−7.63 ± 7.81	−1.17 ± 5.98	−9.43 ± 6.99	−9.75 ± 12.26
	4	−3.72 ± 5.77	−2.25 ± 6.32	−2.50 ± 6.56	−7.50 ± 3.86	−10.58 ± 5.75	−7.00 ± 9.50
	6	−1.72 ± 7.46	−2.50 ± 8.77	4.50 ± 8.11	−10.34 ± 5.79^a	−12.29 ± 4.56^a	0.13 ± 7.22^a
	8	−1.15 ± 6.77	−4.00 ± 7.42	0.50 ± 9.21	−6.34 ± 8.86	−6.86 ± 7.88	−3.63 ± 15.53
	12	−1.29 ± 5.01	−0.25 ± 4.99	0.75 ± 11.2	−3.00 ± 6.19	−3.29 ± 7.44	−5.38 ± 8.59
SBP
	1	0.58 ± 5.31	−6.13 ± 8.13	−9.50 ± 6.52	−5.17 ± 5.67	−12.29 ± 6.13	−4.50 ± 5.00
	2	−13.58 ± 8.68	−12.13 ± 6.21	−6.38 ± 7.45	−10.34 ± 7.54	−15.43 ± 8.67	−10.63 ± 4.95
	3	−13.58 ± 7.67	−10.88 ± 7.10	−7.38 ± 6.00	−16.50 ± 10.00	−10.43 ± 5.04	−11.75 ± 10.30
	4	−4.29 ± 7.70	−7.13 ± 7.22	−10.13 ± 4.81	−11.00 ± 9.09	−14.15 ± 13.4	−4.88 ± 7.83
	6	−6.43 ± 11.37	−3.88 ± 10.52	−3.88 ± 9.64	−6.00 ± 6.53	−8.29 ± 5.72	−5.00 ± 8.47
	8	−7.43 ± 9.36	−9.50 ± 10.50	−1.88 ± 7.08	−12.34 ± 10.10	−11.29 ± 10.90	−1.88 ± 10.20
	12	3.29 ± 6.73	1.50 ± 8.86	2.00 ± 11.26	−1.84 ± 7.08	−5.15 ± 6.81	−3.50 ± 7.14
DBP
	1	0.43 ± 5.58^a	−8.50 ± 7.05^a	−7.50 ± 4.21^a	−3.84 ± 9.15	−10.29 ± 4.86	−6.63 ± 4.82
	2	−5.43 ± 8.81	−7.38 ± 8.67	−4.38 ± 8.01	−6.34 ± 14.72	−11.86 ± 4.42	−9.38 ± 5.79
	3	−9.29 ± 14.11	−4.75 ± 7.36	−7.25 ± 6.96	−16.84 ± 14.6	−7.00 ± 6.00	−10.75 ± 8.54
	4	−5.29 ± 6.63	−5.25 ± 5.67	−3.63 ± 5.00	−10.17 ± 8.25	−9.58 ± 7.67	−3.00 ± 7.18
	6	6.43 ± 7.19^a	−8.50 ± 8.32^a	1.13 ± 7.72^a	−1.17 ± 7.06^a	−11.43 ± 5.90^a	0.25 ± 4.41^a
	8	−0.43 ± 5.58	−7.63 ± 8.60	−2.38 ± 4.74	−5.50 ± 4.86	−9.29 ± 5.77	−1.00 ± 8.19
	12	−0.58 ± 5.75	−1.75 ± 5.83	−0.63 ± 5.17	−5.17 ± 7.01	−7.86 ± 5.51	−4.25 ± 3.80

The data presented as mean ± standard deviation.

HR = heart rate, SBP = systolic blood pressure, DBP = diastolic blood pressure, EM = extensive metabolizer (CYP2D6^*1/^*1, ^*1/^*2), IM_1 = intermediate metabolizer (CYP2D6^*1/^*10, ^*2/^*10), IM_2 = intermediate metabolizer (CYP2D6^*10/^*10).

^aP < 0.05 between EM, IM_1, and IM_2.