. 2018 May 23;33(27):e182. doi: 10.3346/jkms.2018.33.e182

Table 4. The mean and standard deviation of the ratios of CD25_day1 and CD25_day8 to CD25_day0 in each group (EM, IM_1, IM_2) and in the combined IM group (IM_1 + IM_2).

Groups	EM (n = 6)	IM_1 (n = 7)	IM_2 (n = 8)	P value^a	IM_1 + IM_2 (n = 15)	P value^b
CD25_day1/CD25_day0	7.67 ± 8.67	36.38 ± 45.15	15.26 ± 6.87	0.59	28.46 ± 36.03	0.38
CD25_day8/CD25_day0	18.94 ± 12.95	97.21 ± 128.71	137.77 ± 231.93	0.13	117.49 ± 181.43	0.05

CD25 = the chronotropic dose 25, Day1 = single dosing, Day8 = multiple dosing, Day0 = baseline, EM = extensive metabolizer (CYP2D6^*1/^*1, ^*1/^*2), IM_1 = intermediate metabolizer (CYP2D6^*1/^*10, ^*2/^*10), IM_2 = intermediate metabolizer (CYP2D6^*10/^*10).

^aKruskal-Wallis test; ^bMann-Whitney U test.

Table 4. The mean and standard deviation of the ratios of CD25day1 and CD25day8 to CD25day0 in each group (EM, IM_1, IM_2) and in the combined IM group (IM_1 + IM_2).

Table 4. The mean and standard deviation of the ratios of CD25_day1 and CD25_day8 to CD25_day0 in each group (EM, IM_1, IM_2) and in the combined IM group (IM_1 + IM_2).