Fig. 1.
Female C57BL/6 mice were inoculated intracranially with GL-261cells. At 5 days post cell inoculation (termed as day 1 for Ad-RTS-mIL-12+veledimex treatment), mice were dosed with Ad-RTS-mIL-12 5 × 109 vp intracranially and approximately 2 h later, veledimex was administered via oral gavage at 1–30 mg/m2/day on days 1–14. On days 3 and 7, mice in each group were killed to collect serum and tumor samples for evaluation of IL-12 and IFN-γ levels via ELISA. Each histogram depicts the mean ± standard error (N > 4 per time point). *P < 0.05 versus corresponding vehicle