Fig. 3.
Effect of Ad-RTS-mIL-12 on tumor and blood CD8+ and FoxP3+ T cells. Mice bearing 6-day-old intracranial GL-261 tumors were administered intratumorally a single dose of Ad-RTS-IL-12 5 × 109 vp+once daily orally administered veledimex for 14 consecutive days. Tumor and blood were harvested during the active dosing period and 2 weeks after the last veledimex dose. The tumor and blood were analyzed by flow cytometry for the percentage of cytotoxic T cells (CD8) and regulatory T cells (FoxP3) in the tumor (left) and blood (right). Each histogram is the mean ± SEM for 4 mice. *P < 0.05 versus vehicle on respective days