Table 1.

Effects of Increasing Doses of Ad-RTS-mIL-12 Viral Particles in the Presence of a Fixed Dose of Veledimex

Group	Brain veledimex C max	RTS gDNA	IL-12 mRNA	Tumor IL-12
	(ng/g)	(copies/100 ng DNA)	(relative expression)	(pg/mg)
Vehicle+vehicle		0 ± 0	1 ± 1	3 ± 1
V 100 + 1 × 108  vp	515 ± 53	75 ± 50	2 ± 1	0 ± 0
V 100 + 1 × 109  vp	311 ± 99	9657 ± 2641	105 ± 32	15 ± 6
V 100 + 5 × 109 vp	378 ± 68	27511 ± 16109	300 ± 107	80 ± 31

V activator ligand, veledimex, administered orally at a fixed dose of 100 mg/m²/day

All data are presented as group mean ± SEM