Fig. 1.

CREPT was overexpressed in colon cancer cell lines and primary tissues. a The mRNA and protein level of CREPT was upregulated in most of the colon cancer cell lines detected by real-time PCR or western blot respectively. b The protein expression level of CREPT was significantly higher in primary CRC tumors as compared with their adjacent tissues by western blot. c The mRNA level of CREPT in tumors was dramatically elevated compared with their paired adjacent normal tissues from TCGA CRC database. d CREPT mRNA level was significantly increased in tumor tissues compared with normal tissues from TCGA CRC database (P < 0.0001). e Representative immunohistochemistry image of CREPT protein expression in CRC tumor tissues and their adjacent tissues. f Statistics histogram based on H-score of tissue microarray (n = 152) and normal tissues (n = 14) (P < 0.0001). g Disease-free survival in relation to expression was evaluated by the Kaplan–Meier survival curve and the log-rank test (P < 0.05) (g1). (g2) Patients at TNM I and II was defined as early stage