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. 2018 Jun 27;9:2491. doi: 10.1038/s41467-018-04895-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Delayed degradation of mtDNA after DSB in DNA from fibroblasts and the liver of the mutator mouse. a Diagram of wild-type C57BL6/J mtDNA illustrating the location and number of restriction endonuclease sites. Southern blot from mutator and wild-type fibroblasts infected with (b) Ad-mitoScaI-HA and (c) Ad-mitoApaLI-HA at 1, 5, and 10 days post-infection. d Southern blot from mutator and wild-type mice liver 5 days after retro-orbital injections with Ad-GFP, Ad-mitoScaI-HA, or Ad-mitoApaLI-HA. DNA was post-digested with SacI to linearize mtDNA. Zeta-Probe membrane was hybridized with a [α-³²P] dCTP labeled probe covering 11.7 kb of mtDNA