Table 4.

Mediation analysis results

	Paliperidone 3 mg	Paliperidone 9 mg	Paliperidone 15 mg
DE	3.53 (− 0.40, 7.46)	5.16 (1.33, 8.99)	7.18 (2.85, 11.51)
IE_panss	3.03 (0.44, 5.62)	3.18 (0.78, 5.58)	3.78 (1.21, 6.36)
IE_wg	0.28 (− 2.29, 2.85)	− 0.18 (− 2.36, 1.99)	− 1.07 (− 4.85, 2.72)
TE	8.41 (4.37, 12.45)	9.62 (5.98, 13.26)	13.04 (9.12, 16.96)

All models adjusted for age, sex, race, country, relative day of disease onset, total PANSS score at baseline, PSP score at baseline, BARS score at baseline, SAS score at baseline, BMI at baseline

DE: direct effect; IE_panss: indirect effect through the sum of PANSS positive and negative (panss); IE_wg: indirect effect through percent weight gain (wg); TE: total effect

Estimates and CI are obtained via procedures developed in Bellavia and Valeri (2017). We report pooled estimates and pooled confidence intervals from the bootstrap analyses of 50 imputed data sets